Nuclease-resistant immunostimulatory phosphodiester CpG oligodeoxynucleotides as human Toll-like receptor 9 agonists

BACKGROUND: Unmethylated cytosine-guanine (CpG) motif-containing oligodeoxynucleotides (ODNs) have been well characterized as agonists of Toll-like receptor 9 (TLR9). ODNs with a phosphorothioate (PTO) backbone have been studied as TLR9 agonists since natural ODNs with a phosphodiester (PD) backbone...

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Autores principales: Meng, Wenjun, Yamazaki, Tomohiko, Nishida, Yuuki, Hanagata, Nobutaka
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189879/
https://ncbi.nlm.nih.gov/pubmed/21943407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-11-88
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