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Bacterial Display and Screening of Posttranslationally Thioether-Stabilized Peptides

A major hurdle in the application of therapeutic peptides is their rapid degradation by peptidases. Thioether bridges effectively protect therapeutic peptides against breakdown, thereby strongly increasing bioavailability, enabling oral and pulmonary delivery and potentially significantly optimizing...

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Bibliografski detalji
Glavni autori: Bosma, Tjibbe, Kuipers, Anneke, Bulten, Erna, de Vries, Louwe, Rink, Rick, Moll, Gert N.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187086/
https://ncbi.nlm.nih.gov/pubmed/21821759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.05550-11
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