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Bacterial Display and Screening of Posttranslationally Thioether-Stabilized Peptides

A major hurdle in the application of therapeutic peptides is their rapid degradation by peptidases. Thioether bridges effectively protect therapeutic peptides against breakdown, thereby strongly increasing bioavailability, enabling oral and pulmonary delivery and potentially significantly optimizing...

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Main Authors: Bosma, Tjibbe, Kuipers, Anneke, Bulten, Erna, de Vries, Louwe, Rink, Rick, Moll, Gert N.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187086/
https://ncbi.nlm.nih.gov/pubmed/21821759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.05550-11
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