Bacterial Display and Screening of Posttranslationally Thioether-Stabilized Peptides

A major hurdle in the application of therapeutic peptides is their rapid degradation by peptidases. Thioether bridges effectively protect therapeutic peptides against breakdown, thereby strongly increasing bioavailability, enabling oral and pulmonary delivery and potentially significantly optimizing...

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Bibliografiset tiedot
Päätekijät: Bosma, Tjibbe, Kuipers, Anneke, Bulten, Erna, de Vries, Louwe, Rink, Rick, Moll, Gert N.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2011
Aiheet:
Enzymology and Protein Engineering
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187086/
https://ncbi.nlm.nih.gov/pubmed/21821759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.05550-11
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