Rituximab Selectively Suppresses Specific Islet Antibodies

OBJECTIVE: The TrialNet Study Group evaluated rituximab, a B-cell–depleting monoclonal antibody, for its effect in new-onset patients with type 1A diabetes. Rituximab decreased the loss of C-peptide over the first year of follow-up and markedly depleted B lymphocytes for 6 months after administratio...

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Hlavní autoři: Yu, Liping, Herold, Kevan, Krause-Steinrauf, Heidi, McGee, Paula L., Bundy, Brian, Pugliese, Alberto, Krischer, Jeff, Eisenbarth, George S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2011
Témata:
Immunology and Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178300/
https://ncbi.nlm.nih.gov/pubmed/21831969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0674
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