Effect of the disease-causing mutations identified in human RNase H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII

Eukaryotic RNases H2 consist of one catalytic and two accessory subunits. Several single mutations in any one of these subunits of human RNase H2 cause Aicardi-Goutières syndrome. To examine whether these mutations affect complex stability and activity of RNase H2, three mutant proteins of His-tagge...

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Bibliografiske detaljer
Main Authors:	Rohman, Muhammad Saifur, Koga, Yuichi, Takano, Kazufumi, Chon, Hyongi, Crouch, Robert J., Kanaya, Shigenori
Format:	Artigo
Sprog:	Inglês
Udgivet:	2008
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3178050/ https://ncbi.nlm.nih.gov/pubmed/18721139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2008.06622.x
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Effect of the disease-causing mutations identified in human RNase H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII

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