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Protection by Low-Dose Kanamycin against Noise-Induced Hearing Loss in Mice: Dependence on Dosing Regimen and Genetic Background

We recently demonstrated that sub-chronic low-dose kanamycin (KM, 300 mg/kg sc, 2x/day, 10 days) dramatically reduces permanent noise-induced hearing loss (NIHL) and hair cell loss in 1 month old CBA/J mice (Fernandez et al., 2010, J. Assoc. Res. Otolaryngol. 11, 235–244). Protection by KM remained...

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Autori principali: Ohlemiller, Kevin K., Rice, Mary E. Rybak, Rosen, Allyson D., Montgomery, Scott C., Gagnon, Patricia M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175505/
https://ncbi.nlm.nih.gov/pubmed/21645602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heares.2011.05.007
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