Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines

BACKGROUND: The ataxia telangiectasia mutated and Rad3-related kinase (ATR) has a key role in the signalling of stalled replication forks and DNA damage to cell cycle checkpoints and DNA repair. It has long been recognised as an important target for cancer therapy but inhibitors have proved elusive....

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Main Authors: Peasland, A, Wang, L-Z, Rowling, E, Kyle, S, Chen, T, Hopkins, A, Cliby, W A, Sarkaria, J, Beale, G, Edmondson, R J, Curtin, N J
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Translational Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172902/
https://ncbi.nlm.nih.gov/pubmed/21730979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.243
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