Deletion of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Auxiliary Subunit TRIP8b Impairs Hippocampal I(h) Localization and Function and Promotes Antidepressant Behavior in Mice

Output properties of neurons are greatly shaped by voltage-gated ion channels, whose biophysical properties and localization within axodendritic compartments serve to significantly transform the original input. The hyperpolarization-activated current, I(h), is mediated by hyperpolarization-activated...

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Main Authors: Lewis, Alan S., Vaidya, Sachin P., Blaiss, Cory A., Liu, Zhiqiang, Stoub, Travis R., Brager, Darrin H., Chen, Xiangdong, Bender, Roland A., Estep, Chad M., Popov, Andrey B., Kang, Catherine E., Van Veldhoven, Paul P., Bayliss, Douglas A., Nicholson, Daniel A., Powell, Craig M., Johnston, Daniel, Chetkovich, Dane M.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2011
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169171/
https://ncbi.nlm.nih.gov/pubmed/21593326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0936-11.2011
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