An Autoinhibitory Helix in the C-Terminal Region of Phospholipase C-β Mediates Gα(q) Activation

Phospholipase C-β (PLCβ) is a key regulator of intracellular calcium levels whose activity is controlled by heptahelical receptors that couple to G(q). We have determined atomic structures of two invertebrate homologs of PLCβ (PLC21) from cephalopod retina and identified a helix from the C-terminal...

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Huvudupphovsmän: Lyon, Angeline M., Tesmer, Valerie M., Dhamsania, Vishan D., Thal, David M., Gutierrez, Joanne, Chowdhury, Shoaib, Suddala, Krishna C., Northup, John K., Tesmer, John J. G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3168981/
https://ncbi.nlm.nih.gov/pubmed/21822282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2095
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