Enhanced Sialic Acid-Dependent Endocytosis Explains the Increased Efficiency of Infection of Airway Epithelia by a Novel Adeno-Associated Virus

We previously used directed evolution in human airway epithelia to create adeno-associated virus 2.5T (AAV2.5T), a highly infectious chimera of AAV2 and AAV5 with one point mutation (A581T). We hypothesized that the mechanism for its increased infection may be a higher binding affinity to the surfac...

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Detalhes bibliográficos
Main Authors: Dickey, David D., Excoffon, Katherine J. D. A., Koerber, James T., Bergen, Jamie, Steines, Benjamin, Klesney-Tait, Julia, Schaffer, David V., Zabner, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165813/
https://ncbi.nlm.nih.gov/pubmed/21697483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05154-11
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