Enhanced Sialic Acid-Dependent Endocytosis Explains the Increased Efficiency of Infection of Airway Epithelia by a Novel Adeno-Associated Virus

We previously used directed evolution in human airway epithelia to create adeno-associated virus 2.5T (AAV2.5T), a highly infectious chimera of AAV2 and AAV5 with one point mutation (A581T). We hypothesized that the mechanism for its increased infection may be a higher binding affinity to the surfac...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Dickey, David D., Excoffon, Katherine J. D. A., Koerber, James T., Bergen, Jamie, Steines, Benjamin, Klesney-Tait, Julia, Schaffer, David V., Zabner, Joseph
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2011
Gaiak:
Virus-Cell Interactions
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165813/
https://ncbi.nlm.nih.gov/pubmed/21697483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05154-11
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak