Real Time Enzyme Inhibition Assays Provide Insights into Differences in Binding of Neuraminidase Inhibitors to Wild Type and Mutant Influenza Viruses

The influenza neuraminidase (NA) inhibitors zanamivir, oseltamivir and peramivir were all designed based on the knowledge that the transition state analogue of the cleaved sialic acid, 2-deoxy,2,3-dehydro N-acetyl neuraminic acid (DANA) was a weak inhibitor of NA. While DANA bound rapidly to the NA,...

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Bibliographic Details
Main Authors: Barrett, Susan, Mohr, Peter G., Schmidt, Peter M., McKimm-Breschkin, Jennifer L.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157426/
https://ncbi.nlm.nih.gov/pubmed/21858186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023627
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