Loading...

Translesion Synthesis Past the C8- and N(2)-Deoxyguanosine Adducts of the Dietary Mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline in the NarI Recognition Sequence by Prokaryotic DNA Polymerases

2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) is found in cooked meats and forms DNA adducts at the C8- and N(2)-positions of dGuo after appropriate activation. IQ is a potent inducer of frameshift mutations in bacteria and is carcinogenic in laboratory animals. We have incorporated both IQ-adducts i...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Stover, James S., Chowdhury, Goutam, Zang, Hong, Guengerich, F. Peter, Rizzo, Carmelo J.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150502/
https://ncbi.nlm.nih.gov/pubmed/17112239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx0601455
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!