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Using Covalent Dimers of Human Carbonic Anhydrase II to Model Bivalency in Immunoglobulins
This paper describes the development of a new bivalent system comprising synthetic dimers of carbonic anhydrase linked chemically through thiol groups of cysteine residues introduced by site-directed mutagenesis. These compounds serve as models with which to study the interaction of bivalent protein...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3145338/ https://ncbi.nlm.nih.gov/pubmed/21671600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2038084 |
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