Efavirenz and rifampicin in the South African context: is there a need to dose increase efavirenz with concurrent rifampicin therapy?

INTRODUCTION: Increasing EFV dose from 600mg to 800mg daily has been suggested with concomitant RFN, as induction of cytochrome p450 isoenzymes may reduce EFV plasma concentrations METHODS: Individuals from the CIPRA-South Africa cohort taking EFV-based ART with concomitant TB were dosed with either...

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Bibliographic Details
Main Authors: Orrell, Catherine, Cohen, Karen, Conradie, Francesca, Zeinecker, Jennifer, Ive, Prudence, Sanne, Ian, Wood, Robin
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145153/
https://ncbi.nlm.nih.gov/pubmed/21685540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3851/IMP1780
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