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A three-dimensional perspective on exon binding by a group II self-splicing intron

We have used chemical footprinting, kinetic dissection of reactions and comparative sequence analysis to show that in self-splicing introns belonging to subgroup IIB, the sites that bind the 5′ and 3′ exons are connected to one another by tertiary interactions. This unanticipated arrangement, which...

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Main Authors: Costa, Maria, Michel, François, Westhof, Eric
格式: Artigo
語言:Inglês
出版: Oxford University Press 2000
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC314214/
https://ncbi.nlm.nih.gov/pubmed/10990464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.18.5007
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