Evaluation of the Membrane Permeability (PAMPA and Skin) of Benzimidazoles with Potential Cannabinoid Activity and their Relation with the Biopharmaceutics Classification System (BCS)

The permeability of five benzimidazole derivates with potential cannabinoid activity was determined in two models of membranes, parallel artificial membrane permeability assay (PAMPA) and skin, in order to study the relationship of the physicochemical properties of the molecules and characteristics...

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Hauptverfasser: Alvarez-Figueroa, M. Javiera, Pessoa-Mahana, C. David, Palavecino-González, M. Elisa, Mella-Raipán, Jaime, Espinosa-Bustos, Cristián, Lagos-Muñoz, Manuel E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer US 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134672/
https://ncbi.nlm.nih.gov/pubmed/21538213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-011-9622-1
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