Evaluation of the Membrane Permeability (PAMPA and Skin) of Benzimidazoles with Potential Cannabinoid Activity and their Relation with the Biopharmaceutics Classification System (BCS)

The permeability of five benzimidazole derivates with potential cannabinoid activity was determined in two models of membranes, parallel artificial membrane permeability assay (PAMPA) and skin, in order to study the relationship of the physicochemical properties of the molecules and characteristics...

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Main Authors: Alvarez-Figueroa, M. Javiera, Pessoa-Mahana, C. David, Palavecino-González, M. Elisa, Mella-Raipán, Jaime, Espinosa-Bustos, Cristián, Lagos-Muñoz, Manuel E.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134672/
https://ncbi.nlm.nih.gov/pubmed/21538213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-011-9622-1
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