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Phase I Study of Arsenic Trioxide, High-Dose Cytarabine and Idarubicin to Down-Regulate Constitutive STAT3 Activity in <60 Year Old Acute Myeloid Leukemia Patients
PURPOSE: Constitutive activation of signal transducer and activator of transcription-3 (STAT3) was detected in blasts from approximately 50% of acute myeloid leukemia (AML) patients and was found to correlate with adverse outcome. In vitro treatment of AML blasts with arsenic trioxide (ATO) down-reg...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3129468/ https://ncbi.nlm.nih.gov/pubmed/21456022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.26097 |
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