Phosphorylation of Ser 402 impedes phosphatase activity of slingshot 1

By using mass spectrometry, we have identified Ser 402 as a new phosphorylation site within the catalytic domain of human slingshot 1 (SSH1). Phosphorylation at this site inhibits substrate binding and, thus, phosphatase activity in vitro, resulting in enrichment of phosphorylated cofilin in monolay...

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Detalhes bibliográficos
Main Authors: Barišić, Sandra, Nagel, Anja C, Franz-Wachtel, Mirita, Macek, Boris, Preiss, Anette, Link, Gisela, Maier, Dieter, Hausser, Angelika
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128274/
https://ncbi.nlm.nih.gov/pubmed/21525957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.53
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