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Toxicity Testing in the 21(st) Century: Defining New Risk Assessment Approaches Based on Perturbation of Intracellular Toxicity Pathways

The approaches to quantitatively assessing the health risks of chemical exposure have not changed appreciably in the past 50 to 80 years, the focus remaining on high-dose studies that measure adverse outcomes in homogeneous animal populations. This expensive, low-throughput approach relies on conser...

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Autors principals: Bhattacharya, Sudin, Zhang, Qiang, Carmichael, Paul L., Boekelheide, Kim, Andersen, Melvin E.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118802/
https://ncbi.nlm.nih.gov/pubmed/21701582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020887
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