Selected amino acid mutations in HIV-1 B subtype gp41 are Associated with Specific gp120(V3 )signatures in the regulation of Co-Receptor usage

BACKGROUND: The third variable loop (V3) of the HIV-1 gp120 surface protein is a major determinant of cellular co-receptor binding. However, HIV-1 can also modulate its tropism through other regions in gp120, such as V1, V2 and C4 regions, as well as in the gp41 protein. Moreover, specific changes i...

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Main Authors: Dimonte, Salvatore, Mercurio, Fabio, Svicher, Valentina, D'Arrigo, Roberta, Perno, Carlo-Federico, Ceccherini-Silberstein, Francesca
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117778/
https://ncbi.nlm.nih.gov/pubmed/21569409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-8-33
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