Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport

In several neurodegenerative diseases, axonal degeneration occurs before neuronal death and contributes significantly to patients’ disability. Hereditary spastic paraplegia (HSP) is a genetically heterogeneous condition characterized by selective degeneration of axons of the corticospinal tracts and...

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Detalhes bibliográficos
Principais autores: Ferreirinha, Fatima, Quattrini, Angelo, Pirozzi, Marinella, Valsecchi, Valentina, Dina, Giorgia, Broccoli, Vania, Auricchio, Alberto, Piemonte, Fiorella, Tozzi, Giulia, Gaeta, Laura, Casari, Giorgio, Ballabio, Andrea, Rugarli, Elena I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC311437/
https://ncbi.nlm.nih.gov/pubmed/14722615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420138
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