The Role of Calcineurin/NFAT in SFRP2 Induced Angiogenesis—A Rationale for Breast Cancer Treatment with the Calcineurin Inhibitor Tacrolimus

Tacrolimus (FK506) is an immunosuppressive drug that binds to the immunophilin FKBPB12. The FK506-FKBP12 complex associates with calcineurin and inhibits its phosphatase activity, resulting in inhibition of nuclear translocation of nuclear factor of activated T-cells (NFAT). There is increasing data...

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Bibliographic Details
Main Authors: Siamakpour-Reihani, Sharareh, Caster, Joseph, Bandhu Nepal, Desh, Courtwright, Andrew, Hilliard, Eleanor, Usary, Jerry, Ketelsen, David, Darr, David, Shen, Xiang Jun, Patterson, Cam, Klauber-DeMore, Nancy
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108822/
https://ncbi.nlm.nih.gov/pubmed/21673995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020412
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