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Effect of surfactants and pH on naltrexone (NTX) permeation across buccal mucosa

The objective of this pre-formulation study was to systematically investigate the effects of two surfactants (Brij 58(®) and Tween 80(®)) and change in solution pH on in vitro permeation of naltrexone HCl (NTX-HCl) across tissue engineered human buccal mucosa. For the study, 10 mg/mL solutions of Tw...

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Autors principals: Rai, Vishwas, Tan, Hock S., Michniak-Kohn, Bozena
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103779/
https://ncbi.nlm.nih.gov/pubmed/21443939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2011.03.046
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