Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development

Up-regulation of P2X4 receptors in spinal cord microglia is crucial for tactile allodynia, an untreatable pathological pain reaction occurring after peripheral nerve injury. How nerve injury in the periphery leads to this microglia reaction in the dorsal horn of the spinal cord is not yet understood...

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Detalhes bibliográficos
Main Authors: Biber, Knut, Tsuda, Makoto, Tozaki-Saitoh, Hidetoshi, Tsukamoto, Keiko, Toyomitsu, Emika, Masuda, Takahiro, Boddeke, Hendrikus, Inoue, Kazuhide
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101996/
https://ncbi.nlm.nih.gov/pubmed/21441897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.89
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