Proteasome inhibition improves diaphragm function in congestive heart failure rats

In congestive heart failure (CHF), diaphragm weakness is known to occur and is associated with myosin loss and activation of the ubiquitin-proteasome pathway. The effect of modulating proteasome activity on myosin loss and diaphragm function is unknown. The present study investigated the effect of i...

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Bibliographic Details
Main Authors: van Hees, Hieronymus W. H., Li, Yi-Ping, Ottenheijm, Coen A. C., Jin, Bingwen, Pigmans, Cindy J. C., Linkels, Marianne, Dekhuijzen, P. N. Richard, Heunks, Leo M. A.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101573/
https://ncbi.nlm.nih.gov/pubmed/18424622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00035.2008
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