Characterization of a MAPK Scaffolding Protein Logic Gate in Gonadotropes

In the pituitary gonadotropes, both protein kinase C (PKC) and MAPK/ERK signaling cascades are activated by GnRH. Phosphoprotein-enriched in astrocytes 15 (PEA-15) is a cytosolic ERK scaffolding protein, which is expressed in LβT2 gonadotrope cells. Pharmacological inhibition of PKC and small interf...

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Bibliographic Details
Main Authors: Choi, Soon Gang, Ruf-Zamojski, Frederique, Pincas, Hanna, Roysam, Badrinath, Sealfon, Stuart C.
Format: Artigo
Language:Inglês
Published: Endocrine Society 2011
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100603/
https://ncbi.nlm.nih.gov/pubmed/21436256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0387
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