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Asymmetric Enzymatic Glycosylation of Mitoxantrone

[Image: see text] Using a uniquely promiscuous engineered glycosyltransferase (GT) derived from the macrolide-inactivating GT OleD, a single-step asymmetric glucosylation of one ‘arm’ of the drug mitoxantrone was efficiently achieved in high stereo- and regiospecificity. The synthesis, structural el...

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Detalhes bibliográficos
Main Authors: Zhou, Maoquan, Thorson, Jon S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099400/
https://ncbi.nlm.nih.gov/pubmed/21528870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol200977u
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