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Asymmetric Enzymatic Glycosylation of Mitoxantrone
[Image: see text] Using a uniquely promiscuous engineered glycosyltransferase (GT) derived from the macrolide-inactivating GT OleD, a single-step asymmetric glucosylation of one ‘arm’ of the drug mitoxantrone was efficiently achieved in high stereo- and regiospecificity. The synthesis, structural el...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3099400/ https://ncbi.nlm.nih.gov/pubmed/21528870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol200977u |
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