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Ligand-Driven Vectorial Folding of Ribosome-Bound Human CFTR NBD1
The mechanism by which protein folding is coupled to biosynthesis is a critical, but poorly understood aspect of protein conformational diseases. Here we use FRET to characterize tertiary structural transitions of nascent polypeptides and show that the first nucleotide-binding domain (NBD1) of human...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3095512/ https://ncbi.nlm.nih.gov/pubmed/21419343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.02.027 |
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