Clonal Composition of Neuroantigen-specific CD8+ and CD4+ T-cells in Multiple Sclerosis

Patients with multiple sclerosis (MS) show a high prevalence of myelin-reactive CD8+ and CD4+ T-cell responses, which are the putative effectors/modulators of CNS neuropathology. Utilizing a novel combination of short-term culture, CFSE-based sorting and anchored PCR, we evaluated clonal composition...

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Autors principals: Biegler, Brian W., Yan, Shirley X., Ortega, Sterling B., Tennakoon, Deepani K., Racke, Michael K., Karandikar, Nitin J.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092854/
https://ncbi.nlm.nih.gov/pubmed/21397340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2011.02.001
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