DiGeorge Critical Region 8 (DGCR8) Is a Double-cysteine-ligated Heme Protein

All known heme-thiolate proteins ligate the heme iron using one cysteine side chain. We previously found that DiGeorge Critical Region 8 (DGCR8), an essential microRNA processing factor, associates with heme of unknown redox state when overexpressed in Escherichia coli. On the basis of the similarit...

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Autors principals: Barr, Ian, Smith, Aaron T., Senturia, Rachel, Chen, Yanqiu, Scheidemantle, Brooke D., Burstyn, Judith N., Guo, Feng
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089513/
https://ncbi.nlm.nih.gov/pubmed/21454614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.180844
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