TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice

Vascular-disrupting agents (VDAs) such as combretastatin A4 phosphate (CA4P) selectively disrupt blood vessels in tumors and induce tumor necrosis. However, tumors rapidly repopulate after treatment with such compounds. Here, we show that CA4P-induced vessel narrowing, hypoxia, and hemorrhagic necro...

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Detalhes bibliográficos
Main Authors: Welford, Abigail F., Biziato, Daniela, Coffelt, Seth B., Nucera, Silvia, Fisher, Matthew, Pucci, Ferdinando, Di Serio, Clelia, Naldini, Luigi, De Palma, Michele, Tozer, Gillian M., Lewis, Claire E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083764/
https://ncbi.nlm.nih.gov/pubmed/21490397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44562
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