Insertion of the human sodium iodide symporter to facilitate deep tissue imaging does not alter oncolytic or replication capability of a novel vaccinia virus

INTRODUCTION: Oncolytic viruses show promise for treating cancer. However, to assess therapeutic efficacy and potential toxicity, a noninvasive imaging modality is needed. This study aimed to determine if insertion of the human sodium iodide symporter (hNIS) cDNA as a marker for non-invasive imaging...

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Main Authors: Haddad, Dana, Chen, Nanhai G, Zhang, Qian, Chen, Chun-Hao, Yu, Yong A, Gonzalez, Lorena, Carpenter, Susanne G, Carson, Joshua, Au, Joyce, Mittra, Arjun, Gonen, Mithat, Zanzonico, Pat B, Fong, Yuman, Szalay, Aladar A
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080806/
https://ncbi.nlm.nih.gov/pubmed/21453532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-9-36
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