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Activation-Induced Deaminase-deficient MRL/lpr mice secrete high levels of protective antibodies against lupus nephritis
OBJECTIVE: We previously generated MRL/lpr mice deficient in the activation-induced deaminase (AID) who lack isotype switching and immunoglobulin hypermutation. These mice have high levels of unmutated (germline) autoreactive IgM yet experienced an increase in survival and an improvement in lupus ne...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3079514/ https://ncbi.nlm.nih.gov/pubmed/21225690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.30230 |
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