GATA2 Mediates Thyrotropin-Releasing Hormone-Induced Transcriptional Activation of the Thyrotropin β Gene

Thyrotropin-releasing hormone (TRH) activates not only the secretion of thyrotropin (TSH) but also the transcription of TSHβ and α-glycoprotein (αGSU) subunit genes. TSHβ expression is maintained by two transcription factors, Pit1 and GATA2, and is negatively regulated by thyroid hormone (T3). Our p...

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Autori principali: Ohba, Kenji, Sasaki, Shigekazu, Matsushita, Akio, Iwaki, Hiroyuki, Matsunaga, Hideyuki, Suzuki, Shingo, Ishizuka, Keiko, Misawa, Hiroko, Oki, Yutaka, Nakamura, Hirotoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077393/
https://ncbi.nlm.nih.gov/pubmed/21533184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018667
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