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Alternative Splicing as a Therapeutic Target for Human Diseases
The majority of eukaryotic genes undergo alternative splicing, an evolutionarily conserved phenomenon, to generate functionally diverse protein isoforms from a single transcript. The fact that defective pre-mRNA splicing can generate non-functional and often toxic proteins with catastrophic effects,...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3076216/ https://ncbi.nlm.nih.gov/pubmed/19495693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-60327-295-7_10 |
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