High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase

BACKGROUND: Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can form an active protein kinase complex with Leishman...

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Main Authors: Walker, Roderick G., Thomson, Graeme, Malone, Kirk, Nowicki, Matthew W., Brown, Elaine, Blake, David G., Turner, Nicholas J., Walkinshaw, Malcolm D., Grant, Karen M., Mottram, Jeremy C.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071374/
https://ncbi.nlm.nih.gov/pubmed/21483720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001033
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