The central nervous system restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma

High-grade gliomas are notoriously insensitive to radiation and genotoxic drugs. Paradoxically, the p53 gene is structurally intact in the majority of these tumors. Resistance to genotoxic modalities in p53-positive gliomas is generally attributed to attenuation of p53 functions by mutations of othe...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Mehta, Shwetal, Huillard, Emmanuelle, Kesari, Santosh, Maire, Cecile L., Golebiowski, Diane, Harrington, Emily P., Alberta, John A., Kane, Michael F., Theisen, Matthew, Ligon, Keith L., Rowitch, David H., Stiles, Charles D.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2011
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070398/
https://ncbi.nlm.nih.gov/pubmed/21397859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.01.035
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