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The GAS41-PP2Cβ Complex Dephosphorylates p53 at Serine 366 and Regulates Its Stability
The p53 tumor suppressor is principally regulated by post-translational modifications and proteasome-dependent degradation. Various kinases have been shown to phosphorylate p53, but little is known about the counteracting phosphatases. We demonstrate here that the newly identified complex GAS41-PP2C...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3064146/ https://ncbi.nlm.nih.gov/pubmed/21317290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.210211 |
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