Rapid Identification of a Disease Allele in Mouse Through Whole Genome Sequencing and Bulk Segregation Analysis

In a pedigree of C57BL/6J mice homozygous for germline mutations induced by the mutagen N-ethyl-N-nitrosourea (ENU), numerous animals died under specific pathogen-free (SPF) conditions between 6 and 7 months of age. Death was caused by nephritic syndrome, which progressed to renal failure associated...

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Bibliografiska uppgifter
Huvudupphovsmän: Arnold, Carrie N., Xia, Yu, Lin, Pei, Ross, Charles, Schwander, Martin, Smart, Nora G., Müller, Ulrich, Beutler, Bruce
Materialtyp: Artigo
Språk:Inglês
Publicerad: Genetics Society of America 2011
Ämnen:
Investigations
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063661/
https://ncbi.nlm.nih.gov/pubmed/21196518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.110.124586
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