Differential Disposition of Chenodeoxycholic Acid versus Taurocholic Acid in Response to Acute Troglitazone Exposure in Rat Hepatocytes

Inhibition of bile acid (BA) transport may contribute to the hepatotoxicity of troglitazone (TRO), a peroxisome proliferator–activated receptor gamma agonist. Typically, studies use taurocholic acid (TCA) as a model substrate to investigate effects of xenobiotics on BA disposition. However, TRO may...

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Bibliografiske detaljer
Main Authors: Marion, Tracy L., Perry, Cassandra H., St. Claire, Robert L., Yue, Wei, Brouwer, Kim L. R.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
Fag:
IN VITRO Methods and Alternatives to Animals
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061484/
https://ncbi.nlm.nih.gov/pubmed/21262925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfr014
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