Increased Sensitivity of Estrogen Receptor Alpha Overexpressing Antral Follicles to Methoxychlor and Its Metabolites

Methoxychlor (MXC), an organochlorine pesticide, and its metabolites, mono-hydroxy MXC (MOH) and bis-hydroxy MXC (HPTE) are known ovarian toxicants and can cause inhibition of antral follicle growth. Since these chemicals bind to estrogen receptor alpha (ESR1), we hypothesized that ovaries overexpre...

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Bibliographic Details
Main Authors: Paulose, Tessie, Hernández-Ochoa, Isabel, Basavarajappa, Mallikarjuna S., Peretz, Jackye, Flaws, Jodi A.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
Reproductive and Developmental Toxicology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061483/
https://ncbi.nlm.nih.gov/pubmed/21252393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfr011
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