Interleukin-12 Receptor β1 Deficiency Predisposing to Disseminated Coccidioidomycosis

Severe disseminated Coccidioides is rare while localized, contained disease is common. We report a family with disseminated coccidioidomycosis due to a novel homozygous C186Y mutation in interleukin (IL)-12 receptor β1. This family confirms the centrality of the IL-12/IFN-γ axis to human immunity to...

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Bibliografiska uppgifter
Huvudupphovsmän: Vinh, Donald C., Schwartz, Brian, Hsu, Amy P., Miranda, David J., Valdez, Patricia A., Fink, Danielle, Lau, Karen P., Long-Priel, Debra, Kuhns, Douglas B., Uzel, Gulbu, Pittaluga, Stefania, Hoover, Susan, Galgiani, John N., Holland, Steven M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2011
Ämnen:
Electronic Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060907/
https://ncbi.nlm.nih.gov/pubmed/21258095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciq215
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