Unexpected side products in the conjugation of an amine-derivatized morpholino oligomer with p-isothiocyanate benzyl DTPA and their removal

In connection with pretargeting, an amine-derivatized morpholino phosphorodiamidate oligomer (NH(2)-cMORF) was conjugated conventionally with p-isothiocyanate benzyl-DTPA (p-SCN-Bn-DTPA). However, after (111)In radiolabeling, unexpected label instability was observed. To understand this instability,...

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Bibliografiske detaljer
Main Authors: Liu, Guozheng, Dou, Shuping, Liu, Yuxia, Liang, Minmin, Chen, Ling, Cheng, Dengfeng, Greiner, Dale, Rusckowski, Mary, Hnatowich, Donald J
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3052951/
https://ncbi.nlm.nih.gov/pubmed/21315270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2010.08.008
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