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Development of an H(2)(15)O steady-state method combining a bolus and slow increasing injection with a multiprogramming syringe pump

An (15)O-labeled water (H(2)(15)O) steady-state method for quantitative measurement of cerebral blood flow (CBF), which is less stressful to small animals with a few point blood sampling, was developed. After a simulation using a dose meter to achieve stable H(2)(15)O radioactivity in the blood with...

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Detalhes bibliográficos
Main Authors: Kobayashi, Masato, Kiyono, Yasushi, Maruyama, Rikiya, Mori, Tetsuya, Kawai, Keiichi, Okazawa, Hidehiko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049508/
https://ncbi.nlm.nih.gov/pubmed/20664614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.122
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