Cytoplasmic Skp2 Expression Is Increased in Human Melanoma and Correlated with Patient Survival

BACKGROUND: S-phase kinase protein 2 (Skp2), an F-box protein, targets cell cycle regulators via ubiquitin-mediated degradation. Skp2 is frequently overexpressed in a variety of cancers and associated with patient survival. In melanoma, however, the prognostic significance of subcellular Skp2 expres...

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Bibliographic Details
Main Authors: Chen, Guangdi, Cheng, Yabin, Zhang, Zhizhong, Martinka, Magdalena, Li, Gang
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046256/
https://ncbi.nlm.nih.gov/pubmed/21386910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017578
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