Wt1 controls retinoic acid signalling in embryonic epicardium through transcriptional activation of Raldh2

Epicardial-derived signals are key regulators of cardiac embryonic development. An important part of these signals is known to relate to a retinoic acid (RA) receptor-dependent mechanism. RA is a potent morphogen synthesised by Raldh enzymes, Raldh2 being the predominant one in mesodermal tissues. D...

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Autors principals: Guadix, Juan Antonio, Ruiz-Villalba, Adrián, Lettice, Laura, Velecela, Victor, Muñoz-Chápuli, Ramón, Hastie, Nicholas D., Pérez-Pomares, José María, Martínez-Estrada, Ofelia M.
Format: Artigo
Idioma:Inglês
Publicat: Company of Biologists 2011
Matèries:
Research Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042868/
https://ncbi.nlm.nih.gov/pubmed/21343363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.044594
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